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Abstract While several viral infections have been associated with amyotrophic lateral sclerosis (ALS), the mechanism(s) through which they promote disease remains elusive. Here we investigate the impact of common, acute viral infections on ALS disease onset and progression in the SOD1G93A mouse model. A single sublethal infection prior to onset of ALS clinical signs is associated with markedly accelerated ALS disease progression characterized by rapid loss of hindlimb function.
Abstract While several viral infections have been associated with amyotrophic lateral sclerosis (ALS), the mechanism(s) through which they promote disease has remained almost entirely elusive. This study investigated the impact of common, acute viral infections prior to disease onset on ALS progression in the SOD1G93A mouse model.
Highlights • Repeated inactivated influenza vaccination boosts bNAbs • Inactivated and live attenuated vaccines are similarly efficient at boosting bNAbs • The magnitude of IIV and LAIV vaccine-elicited bNAb boosting declines with age Summary The induction of broadly neutralizing antibodies (bNAbs) that target the hemagglutinin stalk domain is a promising strategy for the development of “universal” influenza virus vaccines.
Anomaly 2 ($4.99) by Chillingo Ltd is a 3-D reversed tower-defense game, which can more accurately be described as a tower “offense” game. It is the sequel to the original Anomaly Warzone Earth, which was first released as a PC game. Although most tower defense games are usually very similar, it would be an understatement to say that Anomaly 2 is different. It is so different that it does not even appear to be this type of game until you pick it up and play it.
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