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Articles by Daniel Croagh
Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer - Nature Communications
Abstract Pancreatic ductal adenocarcinoma (PDAC) is driven by genetic alterations in the pancreatic epithelium (e.g., KRAS) coupled with dysregulated innate immunity that triggers tumor-promoting chronic inflammation. However, the identity of innate immune molecular regulators as therapeutic targets in PDAC is ill-defined.
Case Report: Two cases of long-term survival in advanced pancreatic cancer patients following treatment with KRAS G12C inhibitors
Introduction Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, accounting for about 90% of all cases. PDAC ranks as the seventh most common cause of cancer-related mortality worldwide with a five-year survival rate below 10%. However, projections indicate that by 2030, it will rise to become the second leading cause of cancer deaths globally (1).
Supplemental tube feeding: qualitative study of patient perspectives in advanced pancreatic cancer
Most participants acknowledged that supplementary enteral feeding would be an effective intervention to maintain nutrition status and have beneficial impacts on multiple domains of health, including physical and emotional, which outweighed anticipated burdens. Improved tolerance of chemotherapy, increased energy levels and reduced risk of complications were regarded by most participants as notable expected beneficial impacts of the intervention.
EUS guided gastroenterostomy to relieve biliary obstruction due to afferent limb syndrome in complex post-surgical anatomy
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Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma
Open AccessArticle by Loryn Holokai 1,†, Jayati Chakrabarti 2,†, Joanne Lundy 3,4, Daniel Croagh 5, Pritha Adhikary 2, Scott S. Richards 6, Chantal Woodson 1, Nina Steele 7, Robert Kuester 6, Aaron Scott 8, Mohammad Khreiss 8, Timothy Frankel 7, Juanita Merchant 6, Brendan J. Jenkins 3,4, Jiang Wang 9, Rachna T. Shroff 8, Syed A.
Managing choledocholithiasis in pregnancy: a novel approach
Managing choledocholithiasis in pregnancy: a novel approach http://orcid.org/0000-0002-5443-7588Stacey Louise Chamberlain and Daniel Croagh UGI and HPB Surgery, Monash Health, Clayton, Victoria, Australia Correspondence to Dr Stacey Louise Chamberlain; drstaceychamberlain{at}gmail.com Abstract The management of choledocholithiasis in pregnancy can present a challenge due to radiation risk to the fetus and the possibility of severe maternal pancreatitis.
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