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Articles by Daniel Eßer
R Workflow for Semi-Automated LC–HRMS Data Processing for Unveiling Copolymer Distributions
The market size of polyols was estimated at USD 26.2 billion in 2019 and is forecast to reach USD 34.4 billion by 2024.1 In 2018, the polyol market was roughly represented by 25% polyester polyols and 75% polyether polyols. Polyether polyols have been used to produce both flexible and rigid foams. As a result, polyether polyols have been intensively applied in the construction, building, automotive, and other important industries.
SFC 2025 Europe Preview: The Role of SFC in Life Science Analysis
What specific advantages does modern supercritical fluid chromatography (SFC) offer over traditional high performance liquid chromatography (HPLC) when analyzing chiral compounds in pharmaceutical development? John Reily: The integration of supercritical fluid chromatography (SFC) for chiral separation has allowed for productivity increases, decreases in toxic/hazardous solvent consumption, and a greener chromatographic approach.
Native Anion Exchange Chromatography Coupled to Mass Spectrometry for the Charge Variant Analysis of IgG4-based Monoclonal Antibodies
Ion exchange chromatography (IEX) is a standard method for characterizing monoclonal antibodies (mAbs) and ensuring their efficacy. This article discusses the advantages of a native anion exchange method coupled to mass spectrometry (MS) for charge heterogeneity analysis of immunoglobulin G4 (IgG4)-based mAbs, which are currently being studied more intensively.
Improving Chromatographic Results for Oligonucleotides with Column Hardware
The COVID-19 pandemic made it very obvious: oligonucleotide-based drugs are gaining in importance in the treatment of a number of diseases. As a result, research and development and quality control laboratories require robust and sensitive analytical methods. Ion pair (IP) reversed‑phase chromatography is seen as the gold standard for oligonucleotide analysis. This article discusses the main influences in oligonucleotide analysis using IP reversed-phase chromatography.
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