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Discussion Because it is unclear whether previously reported poor outcomes associated with anticholinergic drugs were due to the drugs themselves or to the illnesses they were treating (Andrade, 2019; Coupland et al., 2019), we sought to compare outcomes solely amongst patients receiving these classes of drugs in order to reduce confounding by indication.
Objectives To investigate associations between central anticholinergic burden (determined through the Anticholinergic Effect on Cognition (AEC) scale) and mortality, hospitalisation and cognitive decline in patients with dementia. Methods The South London and Maudsley NHS Foundation Trust (SLaM) Clinical Records Interactive Search (CRIS) application was used to identify patients with a first diagnosis of dementia.
We’re taking a look at stories of some of the sun gods that feature in our collections. Surya and Hinduism In Hinduism, Surya is known as the solar deity and is often represented in iconography as a person riding a chariot of seven horses. This represents seven colours of light and seven days of the week. Surya was one of five deities worshipped throughout India and is ranked highly in the Vedas – a large body of religious texts – which date back to 1500 BC.
Use of anticholinergic drugs in older people is associated with increased risk of cognitive decline and of dementia and death. We identified drugs widely used in older people and attempted to classify their anticholinergic effect on cognition (AEC) according to our three-point scale which scored AEC according to in vitro anticholinergic potency, capacity to cross the blood–brain barrier and statements made in standard texts. In total, 165 drugs were examined.
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