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Abstract The autonomic sympathetic nervous system innervates peripheral resistance arteries, thereby controlling arterial diameter and modulating blood supply to organs and arterial tone. Despite its fundamental role in blood flow regulation and cardiovascular adaptation to challenging situations, how sympathetic arterial innervation develops remains poorly understood.
Loading metrics Open Access Peer-reviewed Research Article Citation: Ben Boubaker R, Henrion D, Chabbert M (2024) Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1). PLoS Comput Biol 20(11): e1012559.
New Results Asma Tiss, Rym Ben Boubaker, Daniel Henrion, Hajer Guissouma, Marie Chabbert doi: https://doi.org/10.1101/2021.06.04.446765 ABSTRACT In vertebrates, the octopeptide angiotensin II (AngII) is an important in vivo regulator of the cardiovascular system. It acts mainly through two G protein-coupled receptors, AT1 and AT2.
Abstract Pseudoxanthoma Elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Although arterial hypertension (AHT) has been reported in PXE patients, its impact on pathological manifestations has as yet been unexplored. We investigated the consequences of experimental AHT on Abcc6−/− PXE mouse models. Experimental AHT was induced by deoxycorticosterone acetate (DOCA-salt) in uni-nephrectomised mice.
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