Professor of Molecular Immunology, Centre Lead for Immunobiology, Barts and The London Medical School, Queen Mary University of London, UK.
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Articles by Daniel J. Pennington
Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors
Abstract Cellular interactions between thymocytes and other immune and stromal thymic cells play a key role in T cell maturation and homeostasis. Previous efforts delineating the cellular interactomes that support T cell development have mostly relied on imaging techniques, genetic deletion of essential molecular factors and bone marrow chimeras.
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms - Nature Immunology
Abstract The contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ heterodimers and expand in preclinical models of infection and cancer. Optimal CD8αβ+ γδ T cell development is directed by low T cell receptor signaling and through provision of interleukin (IL)-4 and IL-7.
Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A-secreting γδ T cells
Research ArticleImmunology View ORCID ProfileNital Sumaria, Stefania Martin, and View ORCID ProfileDaniel J. Pennington* Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK. ↵*Corresponding author. Email: d.pennington{at}qmul.ac.uk See allHide authors and affiliations Science Signaling 20 Jul 2021: Vol.
Developmental origins of murine γδ T‐cell subsets
Summary Murine γδ T cells display diverse responses to pathogens and tumours through early provision of pro‐inflammatory cytokines such as interleukin‐17A (IL‐17) and interferon‐γ (IFN‐γ).
Developmental origins of murine γδ T cell subsets
Murine γδ T cells display diverse responses to pathogens and tumours through early provision of pro‐inflammatory cytokines such as interleukin‐17A (IL‐17) and interferon‐γ (IFNγ). Although it is now clear that acquisition of these cytokine‐secreting effector fates is to a great extent developmentally pre‐programmed in the thymus, the stages through which γδ progenitor cells transition, and the underlying mechanistic processes that govern these commitment events, are still largely unclear.
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