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Dear Editor, Multiple myeloma (MM) is characterized by substantial biological heterogeneity, with outcomes influenced by baseline disease characteristics and depth of response to therapy [1]. Measurable residual disease (MRD) has emerged as a powerful post-treatment prognostic marker; however, assessment of residual disease burden does not directly characterize the proliferative behavior of the remaining clonal plasma cells [2].
Sayeh Fattahi and Daniel G. Packard are co-first authors. This study was presented in part as a proffered paper at the 2026 Annual Congress of the European Society for Radiotherapy and Oncology, Stockholm, Sweden, May 15–19, 2026. Conflicts of Interest T.I.Y. receives in-kind software support from MIM software to support a multicenter pediatric registry and serves on the Scientific Advisory Board for Mevion. N.J.T. chairs the Mevion Medical Advisory Board.
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