CONFLICT OF INTEREST STATEMENT The authors declare the following financial interest/personal relationships, which may be considered a potential competing interest. All coauthors are current or former employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA and may own stock or hold stock options in Merck & Co., Inc., Rahway, NJ, USA. All research activities described in this publication were funded by Merck & Co., Inc., Rahway, NJ, USA. REFERENCES 1.