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Articles by Daniela Iezzi
Sex-specific disruptions in the developmental trajectory of anxiety due to prenatal cannabidiol exposure
Abstract Many pregnant women use cannabidiol (CBD) as a natural remedy to alleviate symptoms such as nausea, insomnia, anxiety, and chronic pain. As much as 20% of pregnancies in the USA and Canada may involve the use of CBD-only products. CBD crosses the placenta and may affect fetal development, potentially leading to neuropsychiatric conditions later in life.
Gestational CBD Shapes Insular Cortex in Adulthood
1. Introduction The growing trend of cannabis use among expectant and nursing mothers is sparking mounting alarm, posing a substantial threat to the well-being of unborn babies and newborns [1,2,3,4,5,6,7]. The two main psychoactive compounds in cannabis, tetrahydrocannabinol (THC) and cannabidiol (CBD), can permeate the placenta during pregnancy (as extensively discussed in Rokeby et al. [8]) and also concentrate in breast milk during lactation.
Gestational CBD shapes insular cortex in adulthood
Abstract Many expectant mothers use CBD to alleviate symptoms like nausea, insomnia, anxiety, and pain, despite limited research on its long-term effects. However, CBD passes through the placenta, affecting fetal development and impacting offspring behavior. We investigated how prenatal CBD exposure affects the insular cortex (IC), a brain region involved in emotional processing and linked to psychiatric disorders.
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex
Abstract Background: The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into sex differences in behavior and cognition. The IC comprises two distinct subregions: the anterior insular cortex (aIC), that processes emotional and social signals, and the posterior insular cortex (pIC), specialized in interoception and perception of pain.
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