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Daniela Malan

As seen in: Nature, BioRxiv
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Articles by Daniela Malan

Optogenetic quantification of source sink relationship in intact hearts to explain cardiac arrhythmia initiation and protection

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By Patrick Boyle, Daniela Malan, Philipp Sasse, Judith S Langen
| BioRxiv
Abstract Increased cardiac excitability and reduced electrical coupling promote cardiac arrhythmia and can be quantified by input resistance (Rm), pacing threshold (Ithr), and cardiac length constant (lambda). However, measurement of these parameters in the heart was not feasible, because the required homogenous current injection cannot be performed with electrical stimulation.
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Author Correction: Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

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By Tobias Bruegmann, Philipp Sasse, Hendrik Lapp, Daniela Malan
| Nature Verified
Correction to: Scientific Reports https://doi.org/10.1038/s41598-017-09760-7, published online 29 August 2017 This Article contains an error in the Experimental Procedures section under subheading ‘Cell culture and generation of ChR2-expressing cardiomyocytes’, where data is omitted in the first paragraph, “1 × 106 Cor4U cardiomyocytes derived from hiPSC were purchased from Axiogenesis (Cologne, Germany) and cultivated in Cor4U Complete Culture Medium (Axiogenesis) in T25 flasks.
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