Daniela Payne
Ontario
Writer | Editor | Yoga teacher
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Articles by Daniela Payne
Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells | Cancer Research
Tumor Biology and Immunology Alyssa D. Smith, Chunwan Lu, Daniela Payne, Amy V. Paschall, John D. Klement, Priscilla S. Redd, Mohammed L. Ibrahim, Dafeng Yang, Qimei Han, Zhuoqi Liu, Huidong Shi, Thomas J. Hartney, Asha Nayak-Kapoor and Kebin Liu DOI: 10.1158/0008-5472.CAN-19-3670 Published August 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.
Autocrine IL6-mediated activation of the STAT3-DNMT axis silences the TNFα-RIP1 necroptosis pathway to sustain survival and accumulation of myeloid-derived suppressor cells
Research Article Alyssa D. Smith, Chunwan Lu, Daniela Payne, Amy V. Paschall, John D. Klement, Priscilla S. Redd, Mohammed L. Ibrahim, Dafeng Yang, Qimei Han, Zhuoqi Liu, Huidong Shi, Thomas J. Hartney, Asha Nayak-Kapoor and Kebin Liu DOI: 10.1158/0008-5472.CAN-19-3670 Abstract Although accumulation of myeloid-derived suppressor cells (MDSC) is a hallmark of cancer, the underlying mechanism of this accumulation within the tumor microenvironment remains incompletely understood.
Join the Local Love Gratitude Challenge @ReadLocalLove
Picture this: It’s bedtime at my house, and my three-year-old is running around naked. Once cornered, he squirms and refuses to get into his PJs, and then insists on dragging out his toothbrushing particularities endlessly. And just when he’s climbed into bed, he announces, “I have to poo!” All the while, my five-year-old son is in the bath, reciting all the potty words he knows at top decibel level and splashing water everywhere, like the bath is his private ocean.
3 amazing ways animals are helping people in the GTA
PHOTOGRAPHY BY EMMA PERRY These stories will make you feel warm and fuzzy about the special animal companions in our community BY LOCAL LOVE Many studies have confirmed what we know in our hearts—that our furry, feathered and scaly friends keep us calm, lower our blood pressure, and help ease anxiety and depression. And that’s just what companion animals achieve. Service animals do even more to support their humans, in many cases making the tasks of daily living not just possible but also joyful.
How SafePet helps women leave abusive relationships by @ReadLocalLove
Taryn Rive knew she had to get away from her abusive partner. She also understood that she and her child would have to leave behind everything they had in order to do it. But the idea of fleeing without her beloved cat, Phoebe, stopped her cold. “No shelter that I knew of would take animals [in this situation],” she says. “That’s one of the reasons why I stayed as long as I did.” When women are being abused, no one, naturally, is thinking about their pets.
5 feel-good stories to make you smile from @ReadLocalLove
Illustration by Lauren Emery Need the perfect antidote to December’s overload of turkey, eggnog and obligatory socializing? Here it is: good-news stories about people who are doing awesome things across the GTA. Just snuggle up on your couch (with one last cookie if you like; we’ll join you!) and dig in to five of our fave stories that will warm you up from the inside out.
How to have a conversation with *that* racist relative by @ReadLocalLove
Illustrations by Katie Carey One night last fall, Alanna* stood at her parents’ sink, washing up after a family dinner party. Through the clanking of silverware, she heard snippets of a conversation her sister and brother-in-law were having in the living room, complaining about the changes to the neighbourhood with the arrival of new immigrant families.
“Food or tampons” isn’t a decision anyone should have to make
Imagine having to decide whether to spend what little money you have on something to eat, or a box of pads? It’s a choice many women and trans men experiencing homelessness must make monthly. Those who choose food often resort to homemade menstrual supplies, using everything from leaves and ripped up clothing to old newspapers. Many go without any form of protection at all. To help tackle this issue, Jana Girdauskas launched The Period Purse in 2017.
The ultimate summer outdoor entertaining guide
Feature
4 ways to get your barbecue ready for grilling season
Don't enter the season without spring cleaning your most important cooking tool — the barbecue. Here's how to tune your grill up on a budget. Remember how much you used your barbecue last summer? Before you start grilling away to the same extent this year, it's important to show your grill a little tender love and care.
Can acupuncture really boost my fertility?
After trying to get pregnant for three months, Nicole Musial’s friend suggested she try acupuncture to help boost her fertility. Eager to move the process along, Musial started seeing a registered traditional Chinese medicine practitioner and acupuncturist once a cycle. At each appointment, she would have a brief chat with her acupuncturist, then lie on a treatment table as the needles were painlessly inserted into various spots on her body.
Ever since my first son was stillborn, I don’t trust my body
“It looks like you have twins in there.” “Is your doctor sure about your due date?” “You’re so much bigger than me and I’m further along than you!” The first time I was pregnant, I was so excited, I was willing to talk to anyone who asked about my apparently enormous belly. But every time, I’d leave those interactions feeling deflated, teary and convinced that something was wrong with me. Was I really that big? Then, just over a week after my due date, my beautiful, huge baby died inside my womb.
9 questions to ask before choosing a midwife
Want to ensure you choose the right person to deliver your baby? Asking a midwife about these key issues will ensure you find a good fit. Once you decide you want a midwife to care for your growing family, it’s important to find one who you’re comfortable with and trust.
10 quick clutter busters
Follow these simple tips to keep clutter at bay and keep your home looking effortlessly organized. Piles of bills on the kitchen counter, DVDs strewn about the living room and a beautiful antique dining room tabletop that's buried under piles of paper. Oh, and you can't find your gym pass either. Can you relate to the above scenario? If so, you and your loved ones may slowly be drowning in a giant pile of clutter. Clutter can be a big weight on the state of your mental health.
How to talk about mental health with your kids
Photo: iStockphoto Talking to kids about mental illness is hard—so hard that many of us put it off indefinitely, not wanting to expose them to things like depression or overwhelming anxiety when they’re so young and innocent. But rather than keeping kids in the dark, it’s essential to learn how to talk about mental health with them to help them feel comfortable talking about their own worries and end the stigma before it begins.
Ever since my first son was stillborn, I don’t trust my body - Today's Parent
“It looks like you have twins in there.” “Is your doctor sure about your due date?” “You’re so much bigger than me and I’m further along than you!” The first time I was pregnant, I was so excited, I was willing to talk to anyone who asked about my apparently enormous belly. But every time, I’d leave those interactions feeling deflated, teary and convinced that something was wrong with me. Was I really that big? Then, just over a week after my due date, my beautiful, huge baby died inside my womb.
My stillborn son's birthday was the worst day of my life
My stillborn son’s birthday was the worst day of my life My stillborn son’s birthday was the worst day of my life In early 2013, I became pregnant with my first child. Excited to start a family, my husband and I bought a house in Toronto’s Corso Italia area. We planned to bring our baby into the world in our new home. When I was about 20 weeks along, we found out we were expecting a boy. As my due date approached, we grew giddy with anticipation. I was huge and felt ready.
Gift guide: 11 best cookbooks for food-loving friends
Our how-to guide has everything you need to host a wild holiday party.
3 tips for a happy Easter (and a fab giveaway)
Easter is almost here, and that means a three day weekend for some of us (yay!). I often find Easter weekend flies by and, between shuffling from house to house for family obligations, I barely get a moment to myself. It's always a fun weekend, but it can also be a little tiring. This year I vow to block off some time to do a few things I enjoy. Here are 3 ways to enjoy your Easter weekend 1. Get outside Ham. Frittata. Broccoli Salad. Egg Bread. Chocolate.
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