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3. Discussion The emergence of evidence has revealed that TRPM2, a highly Ca2+ permeable cation channel, acts as a regulator in cancer growth and survival, and is correlated with poor prognosis in patients with breast, gastric, pancreatic, prostate, head and neck cancers, melanoma, and neuroblastoma. In contrast, in a small number of malignancies, the activation of TRPM2 reduces tumor cell survival.
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