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Get full access to this article View all access and purchase options for this article. References 1. Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. https://doi.org/10.1016/j.diabres.2021.109119 2. Zhang Y, Lazzarini PA, McPhail SM, van Netten JJ, Armstrong DG, Pacella RE.
Highlights • 1.Overexpression of MMP-9 is associated with Notch1 signaling in diabetic skin. • 2.RAGE/Notch1/NF-κB/MMP-9 pathway is activated in AGEs-stressed keratinocytes. • 3.Inhibition of MMP-9 activation by Notch signaling promotes diabetic wound closure. Abstract Aims To elucidate the relationship between advanced glycation end products (AGEs), Notch1 signaling, nuclear factor-kappa B (NF-κB), and matrix metalloproteinase-9 (MMP-9) in diabetic wound healing in vitro and in vivo.
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