Methods The protocol will be conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines (see online supplemental file 1).17 This protocol was preregistered in the International Prospective Register of Systematic Reviews database (registration number: CRD42021278271, registration date: 12 October 2021). The study period was scheduled for 2 years after subject registration (full study duration November 2021–November 2023).