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1 Introduction Neuroblastoma originates from the sympathetic ganglion or bilateral adrenal gland and is one of the most common extracranial solid tumors in childhood (1). Neuroblastoma is characterized by early onset age and a high frequency of metastasis, and clinical studies have shown that approximately 73% of patients have metastases at the time of diagnosis (2). In high-risk neuroblastoma patients, long-term survival is less than 50%, and relapse survival is less than 10% (3).
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