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Articles by Daqing Sun
Engineered bacteria and engineered probiotics for intestinal disease therapy: a bibliometric and knowledge mapping analysis
Abstract Objective: Engineered bacteria and engineered probiotics are emerging living therapeutic platforms for intestinal diseases, supported by advances in synthetic biology, genetic engineering, and microbiome technologies. This study aimed to characterize the research landscape, knowledge structure, research hotspots, and emerging trends of engineered bacteria and engineered probiotics for intestinal disease therapy using bibliometric and knowledge mapping approaches.
Bibliometric analysis of clinical treatment in Hirschsprung disease: trends and emerging hotspots
Abstract Background: Hirschsprung disease (HSCR) is a congenital gastrointestinal malformation defined by the absence of enteric ganglion cells in the distal bowel. Although surgical resection remains the primary treatment, the field has witnessed rapid evolution toward precision minimally invasive strategies, including laparoscopic/robotic-assisted procedures and standardized perioperative protocols. The expanding literature volume necessitates a systematic synthesis of the research landscape.
Sodium butyrate ameliorates intestinal motility and is associated with enteric neuroimmune changes in slow transit constipation mice
Abstract Background: The pathogenesis of slow transit constipation (STC) is still not fully elucidated, and there are no related specific drugs currently available for clinical use. Therefore, our study combined 16S ribosomal RNA (rRNA) gene sequencing, untargeted metabolomics, transcriptomic analysis, and a mouse intervention model to characterize the alterations associated with STC and to evaluate the effects of sodium butyrate (NaB).
Precision minimally invasive strategy for Hirschsprung’s disease: from anatomical resection to whole-cycle functional management—a review
Abstract Background: Minimally invasive radical surgery for Hirschsprung's disease (HD) has achieved substantial advances in anatomical accuracy and perioperative safety, yet postoperative defecation dysfunction remains a key factor limiting long-term quality of life in pediatric patients. Existing reviews seldom elaborate the integrated whole-cycle functional management paradigm.
Acteoside alleviates slow transit constipation with attenuation of NLRP3 inflammasome activation and preservation of enteric neurons
Abstract Background: Slow transit constipation (STC) is characterized by delayed intestinal transit and impaired defecation, with enteric nervous system (ENS) injury and inflammatory dysregulation contributing to its pathogenesis. Acteoside (ACT), a natural phenylethanoid glycoside, has anti-inflammatory and neuroprotective properties. However, its therapeutic effect and mechanism in STC remain unclear.
Inhibition of angiogenesis by propranolol in infantile hemangiomas via lncRNA NEAT1-mediated miR-194-5p/TRAF6/NF-κB pathway
Abstract Existing studies suggest that nuclear paraspeckle assembly transcript 1 (NEAT1) is involved in the biological behavior of endothelial cells by regulating angiogenesis. Treatment of infantile hemangioma (IH) with propranolol (Pro) has been shown to block nuclear factor-κB (NF-κB)-mediated angiogenesis. However, the underlying mechanisms remain unclear.
Multiline treatment of primary cutaneous adenoid cystic carcinoma with multiple metastases: a case report and literature review
1 Introduction Adenoid cystic carcinoma (ACC) is a rare histological subtype that most commonly arises in the major and minor salivary glands but can also occur in other anatomical sites, including the breast, trachea, lungs, cervix, lacrimal glands, and skin (1). ACC arising in the skin, in the absence of involvement of other body sites, is defined as primary cutaneous adenoid cystic carcinoma (PCACC) (2).
Advances in Research on Risk Factors and Development of Risk Prediction Models for Cognitive Frailty in Maintenance Hemodialysis Patients
• , , , et al., “ The Global, Regional, and National Patterns of Change in the Burden of Chronic Kidney Disease From 1990 to 2021 ,” BMC Nephrology ( ): , https://doi.org/10.1186/s12882-025-04028-z. • , “ Current Status and Future of Nephrology in China ,” Journal of China Medical Information Review ( ): , https://doi.org/10.3760/cma.j.issn.1000-8039.2021.05.129.
Rhynchophylline Reverses Obesity in High-Fat Diet-Induced Obese Rats by Regulating the Inflammatory Cascade and Blocking 3-hydroxy-3-methylglutaryl Coenzyme A Reductase
ACS Omega Cite this: ACS Omega 2025, 10, 27 Click to copy citationCitation copied! . This publication is licensed under CC-BY-NC-ND 4.0 . You are free to share (copy and redistribute) this article in any medium or format within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted.
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling - Communications Biology
Abstract Spermatogenesis is an extremely complex process, and any obstruction can cause male infertility. RhoGDIα has been identified as a risk of male sterility. In this study, we generate RhoGDIα knockout mice, and find that the males have severely low fertility. The testes from RhoGDIα−/− mice are smaller than that in WT mice. The numbers of spermatogonia and spermatocytes are decreased in RhoGDIα−/− testis.
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