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Articles by Darius J. R
A preclinical randomised controlled dose optimization of megadose sodium ascorbate for reversal of gram-negative sepsis-induced cardiovascular, brain and kidney dysfunction | Critical Care | Springer Nature Link
The main finding of this study is that in ovine Gram-negative sepsis, only the highest megadose of intravenous sodium ascorbate (3.0 g/kg) effectively enabled withdrawal of vasopressor support, improved renal function, and restored animals to a normal, healthy clinical state. This dose achieved a plasma ascorbate concentration of ~ 10 mmol/L, which is substantially higher than the levels reported in preclinical and clinical studies of vitamin C in sepsis.
Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial - Critical Care
This study was a pilot, single-dose, single-center, double-blind, and randomized controlled trial conducted in a tertiary hospital in Melbourne, Australia. Ethics approval was obtained from Austin Health Human Research Ethics Committee (HREC/64579/Austin-2020, approval date: September, 17, 2020) and the trial was registered with the Australian New Zealand Clinical Trial Registry (ACTRN12620000651987) before the start of enrolment.
Perturbed iron biology in the prefrontal cortex of people with schizophrenia
Molecular Psychiatry, Feb 2023 This is a preview of a remote PDF: https://www.nature.com/articles/s41380-023-01979-3.pdf Lotan, Amit, Luza, Sandra, Opazo, Carlos M., Ayton, Scott, Lane, Darius J. R., Mancuso, Serafino, Pereira, Avril, Sundram, Suresh, Weickert, Cynthia Shannon, Bousman, Chad, Pantelis, Christos, Everall, Ian P., Bush, Ashley I.. , Molecular Psychiatry, DOI: 10.1038/s41380-023-01979-3
Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases
Introduction While the presence of iron is vital for normal function and development of the brain, excess iron deposition has been proposed to play an important role in the pathology of neurodegenerative diseases (Morris et al., 2018). Iron is a key element in several metabolic pathways throughout the body including oxidative phosphorylation and DNA synthesis and is responsible for oxygen transport in the blood.
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