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According to the American Cancer Society, lung cancer is the second most common cancer in both men and women (other than skin cancer). Lung cancer accounts for about 27 percent of all cancer deaths – each year, more people die of lung cancer than of colon, breast and prostate cancers combined. About 221,200 new cases of lung cancer will be diagnosed and approximately 158,040 people will die from lung cancer in the United States this year.
The insulin-like growth factor (IGF) pathway is a complex pathway involving interactions between membrane-bound receptors, ligands, binding proteins, downstream effectors, and other receptor tyrosine kinase signaling cascades. The IGF pathway has been identified as a potential therapeutic target in non-small cell lung cancer (NSCLC) based on the following provocative factors.
Several months ago, Dr. Bilimoria and his colleagues published the long awaited study in NEJM essentially contradicting adverse effects of strict duty hours on patient outcomes (N Engl J Med. 2016 374:713-2). The study, known as the FIRST trial, was published in the March issue of Thoracic Surgery News.
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