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ML, MG, SS and DM are founders of a company, which has the ambition to develop DNAm-based biomarkers for a variety of conditions, including PCC. The other authors declare no competing interests. This work was supported by the Swedish Heart Lung foundation, as a sub-project within the project: Deciphering infection related epigenetic dynamics to explain the variability of human susceptibility to COVID-19 and tuberculosis (Grant no. 2022-0034).
New Results doi: https://doi.org/10.1101/2023.03.07.531501 Abstract Data analysis in systems medicine often employs knowledge-driven approaches, which leverage prior biological insights to guide and inform the study of large omic sets. However, the current state of knowledge in biology is still partial and biased. For example, cancer-associated genes are overrepresented in protein interaction networks. As a result, these approaches may fail to capture novel or unexpected phenomena.
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