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Highlights • FT218 is an investigational once-nightly sodium oxybate (SO) for the treatment of narcolepsy. • FT218 pharmacokinetics (PK) in healthy adults support once-nightly dosing. • Overall exposure, variability, and safety were similar to twice-nighty SO. • Cmax, C8h, and food effect were lower, with dose proportionality. • FT218 PK suggest potential clinical therapeutic benefits over twice-nightly SO.
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