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1 Introduction Francisella tularensis, a Gram-negative bacterium, is the causative agent of tularemia, a zoonotic systemic disease (McCoy and Chapin, 1912). There are various clinical forms of this disease depending on how it is transmitted. The type A strain of F. tularensis is one of the most lethal to humans. It is spread by aerosols, with an infectious dose of only 10 colony-forming units (CFUs) and a mortality rate of 60% in untreated cases.
1 Introduction Francisella tularensis, an intracellular bacterium, is one of the most virulent pathogens classified under Category A as a Potential Bioterrorism Agent. The pathogen causes tularemia, a zoonotic disease for which there is currently no licensed vaccine available and that generally is treated by antibiotics (1). F. tularensis has the ability to infect many different hosts, such as mammals, fish, amphibians, protozoa and arthropods.
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