David Vance
Birmingham
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Articles by David Vance
Identification of candidate markers for the isolation of neuron-specific extracellular vesicles
Abstract Extracellular vesicles (EVs) are present in biofluids and may be useful biomarkers to non-invasively monitor brain cells, but isolating cell type-specific EVs remains challenging. Here we introduce an approach to immuno-isolate EVs from neurons and glia based on protein surface markers. We first selected transmembrane proteins suitable as cell type-specific EV markers based on gene expression and EV proteomic data.
2019's Top Real Estate Niche for Low-Effort, High-Reward Wealth Building
Forum Categories All Rental Property Investor · The Woodlands, TX · Member since 2016 · 2 posts · 0 votes 2y Join the conversationCreate a free account to reply, vote on answers and follow this thread.
Seven PMs in twelve years: What has gone wrong with British democracy?
Narendra Modi has been India’s prime minister for just over 12 years. In that span, the United Kingdom has gone through an astonishing seven prime ministers — from David Cameron and Theresa May to Boris Johnson, Liz Truss, Rishi Sunak, Keir Starmer, and now Andy Burnham, who is set to take office today. The British parliamentary system can be seen to be dysfunctional. What has caused the ‘Mother of All Parliaments’ to become so broken?
US-Iran agreement: Trump’s deal to nowhere
I supported the war against the Islamic Republic of Iran for three basic reasons. The first was moral: since 1979, the Islamic Republic has ruled with a brutal hand, stripping away liberty from millions of Iranians. The second was strategic: a nuclear-armed Iran would be a threat not just to the region, but to the wider world. The third was political: if the Middle East could be reordered in a way that reduced Iran’s reach, it might be possible to build something more stable in its place.
The new West Asian order: Trump’s Frankenstein monster
Sometimes the smallest detail in a big story tells you everything. That’s what’s happening right now with this Iran nuclear deal. What looks like just another diplomatic patch-up is hiding something much bigger: a fundamental shake-up in West Asian power politics, with consequences that will stretch way beyond the region. For the first time in years, we’re seeing a pragmatic coming-together of Sunni and Shia interests that could end up mattering more than the Abraham Accords ever did.
Operation Sindoor redrew India’s anti-terror doctrine with decisive force
The first anniversary of Operation Sindoor is a moment for India to celebrate a tremendous military success, mourn lost civilians, and to signal a permanent shift towards a far more aggressive doctrine against Pakistan-based terror groups. As I said at the time, it also carried important lessons for the broader international community.
The Islamabad mediation circus: A fox guarding the henhouse
I have said it before, and I will say it again: it’s deeply worrying how readily the United States has accepted Pakistan as some kind of honest broker in the high-stakes talks with Iran. Watching Islamabad slide from the sidelines straight into the spotlight of this so-called US-Iran “peace process” feels like watching a masterclass in diplomatic cynicism.
Islamabad was always the wrong choice for Iran talks
By choosing Pakistan as the venue for US-Iran talks, Washington has handed a propaganda coup to a country with zero credibility as a neutral broker. In my view this was not just a misstep; it was an appalling error of judgement. Pakistan – a state riddled with duplicity, economic desperation and strategic opportunism – was never fit to host negotiations of this magnitude. India, by contrast, stood ready as the obvious, superior alternative. And was ignored.
How Iran’s attacks on Gulf states have forged a new alliance in West Asia
It may seem counter-intuitive, but the ongoing war with Iran has done more than just neutralise the immediate threats from the Tehran regime. I believe that it is fundamentally altering the geopolitical landscape of the entire Middle East in ways which will have global consequences for us all. Whilst the conflict may have started out as a targeted campaign against Iran’s nuclear ambitions and ballistic missile programmes, it has now triggered a remarkable realignment.
NDR vs. Illumio Insights: Detecting and Containing Lateral Movement in the Hybrid Cloud
For years, network detection and response (NDR) platforms have served as the security team’s microscope. They inspect network traffic at the packet level, analyze behavior across infrastructure, and surface suspicious activity hidden inside complex environments. When something goes wrong, NDR tools help investigators reconstruct what happened. That capability made sense when most applications lived inside data centers and traffic flowed through predictable network paths.
How Iran war is Pakistan’s worst strategic nightmare
As we enter the second week of the US-Israeli war on Iran’s regime — following the joint airstrikes that began on 28 February — Pakistan should view the unfolding situation with profound anxiety. The conflict, now targeting Iranian military infrastructure, missile sites, nuclear facilities, and even oil storage depots and refining facilities, is raging on Pakistan’s western flank.
Waiting for the hammer: Iran’s regime on the brink as Trump holds the final nail
Since the beginning of January in the heart of the Middle East, the Iranian regime has been unravelling like a frayed rope under too much strain. Right now, the Islamic Republic faces its most existential crisis since the 1979 revolution. Nationwide protests that ignited in late 2025 have morphed into a full-throated demand for regime change, met with a savage crackdown that’s left tens of thousands dead.
Cloud Detection and Response (CDR) Is Evolving. Here’s Where Illumio Insights Fits.
Cloud detection and response (CDR) is a crowded category. New platforms promise better visibility, faster detection, and simpler response, and many deliver real value. But as environments sprawl across cloud, on-premises, containers, and hybrid infrastructure, detection alone is proving insufficient. Visibility without control doesn’t stop attackers. Most organizations already detect threats quickly. The real problem is what happens next.
MICC and ACC collaborate on innovative contracting solutions
RALEIGH-DURHAM, N.C.-Leaders from the 419th Contracting Support Brigade, Mission and Installation Contracting Command, attended a leader professional development session Jan. 21, 2026, hosted by the Army Research Laboratory, focused on expanding the use of innovative contracting tools to meet emerging operational requirements.
Starmer’s desperate dash to India: How PM Modi holds all the cards against Britain
British Prime Minister Sir Keir Starmer travels to India on 8-9 October for his first overseas visit there since taking over the office. While it is a good thing that the UK and India can enjoy good relations at an international level, I think that PM Modi must be careful for several reasons that I will now explain. Starmer, like Trump, wants to be friends with India and Pakistan. I think this is impossible and that it is India where the priority should be afforded.
Starmer’s desperate dash to India: How PM Modi holds all the cards against Britain
Trump says trade talks 'complicated' but Canada will be 'very happy' with eventual deal US President Donald Trump says that trade negotiations are "complicated", but that Canada will be "very happy" with any deal in the future. Speaking alongside Canadian Prime Minister Mark Carney during a cordial meeting at the White House, Trump said that car companies "hurt" the US by setting up …
Why Trump’s tariffs on India are a colossal mistake
As a long-term Donald Trump supporter, it pains me to see the mistakes he is making regarding his treatment of India. Slapping India with 50 per cent tariffs is total madness! Starting August 7, a 25 per cent levy, then another 25 per cent penalty for buying Russian oil—framed as “secondary tariffs” to squeeze Moscow over Ukraine. But this isn’t smart. It’s a blunder that alienates a powerhouse ally, hurts America’s wallet, and weakens its global clout.
Why Trump’s tariffs on India are a colossal mistake
Why Trump’s War on the Drug Cartels Is Bound to Backfire MEXICO CITY — For months, Mexican business officials have gathered in a sleek conference room of the American Chamber of Commerce here to learn about a U.S. threat to their firms that isn’t a tariff. The topic? President Donald Trump’s labeling of several Mexican and other cartels and gangs as …
Operation Sindoor: A resounding success in India’s counter-terrorism strategy
The genesis of Operation Sindoor can be best understood in the many years of terrorist provocation from the failed rogue state of Pakistan but more specifically it is a direct response to the Pahalgam terror attack that took place on April 22, 2025, claiming 26 civilian lives. This lethal and barbarous terrorist attack was the deadliest India had seen on civilians since the 2008 Mumbai attacks and it required a very strong response.
Protocol for a Pilot Randomized Controlled Trial of a Resilience Inter
Introduction The percentage of people living with HIV (PLHIV) in the USA aged 50+ years is predicted to reach 73% by 2030.1 PLHIV experience unique burdens of managing a chronic illness as well as higher rates of trauma, socioeconomic adversity, stigma, and other life stressors than people without HIV, which are associated with poorer health behaviors and outcomes.
The Book Pile
April 18, 2025 Have you heard of GK Chesterton? (No he's not that cheese-puff cat). WATCH KELLEN'S NEW COMEDY SPECIAL ON YOUTUBE!https://www.youtube.com/watch?v=JpBt0W1zrDU&t=1237s KELLEN ERSKINE IS IN ON TOUR! APR 25-26 Indiana MAY 9-10 Dallas MAY 17 St Charles, ILFor tickets go to KellenErskine.co… March 27, 2025 SUMMARY: This episode has everything you could hope for. Conspiracy theories. Hermione exoneration. And a rat who turns out to be a murderer.
Development of a refined harmonization approach for longitudinal cognitive data in people with HIV
aDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USA bDepartments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA cDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA dDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA eDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School...
A type-specific B cell epitope at the apex of Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi
Abstract Broadly protective immunity to the Lyme disease spirochete, Borreliella burgdorferi, is constrained by an overwhelming antibody response against type-specific epitopes on Outer surface protein C (OspC), a homodimeric helix-rich lipoprotein essential for early stages of spirochete dissemination in vertebrate hosts. However, the molecular basis for type-specific immunity has not been fully elucidated.
Labour’s class war on our Farmers!
Be under no illusion – this Labour Government despises our Farming community and wants it gone. DO JOIN MY SUBSTACK HERE! BUY ME A COFFEE HERE AND SUPPORT MY WORK ON THIS PODCAST! Consider protecting your financial freedom by buying GOLD!
Cyber risk management: Key takeaways from Black Hat 2024
Product updates from Black Hat 2024 help security teams better manage constantly changing attack surfaces and ensure new AI projects won't pose security risks. By David Vance, Senior Analyst Published: 16 Aug 2024 This year’s Black Hat USA conference showcased the latest attack methods and news from vendors to help security teams better protect their organizations.
5 key capabilities for effective cyber-risk management
Faced with relentless cyberattacks, organizations need to shore up their cyber-risk management programs by updating legacy tools and checking out new vendor options. By David Vance, Senior Analyst Enterprise Strategy Group We provide market insights, research and advisory, and technical validations for tech buyers. Published: 29 Jul 2024 As organizations are increasingly bombarded with cyberattacks, and with CISOs' jobs on the line, there is increased focus on cyber-risk.
Self-Esteem Among U.S. African American and Latinx Adolescents With Depressive Symptoms and Overweight and/or Obesity
(2013). Big and beautiful? Evidence of racial differences in the perceived attractiveness of obese females. Journal of Adolescence, 36(3), 539–549. 10.1016/j.adolescence.2013.03.010 PMID: 23591377 > Crossref MedlineGoogle Scholar . (2022). Self-esteem. https://dictionary.apa.org/self-esteem > Google Scholar (2011). Major depressive disorder in the African American population. Journal of the National Medical Association, 103(7), 548–557.
A meeting of minds to keep opposition alive
NEVER was it more important for those of us who, from since before lockdown, have been fighting for our freedom and against the decay of our democracy, to hold the line and continue to challenge the establishment narrative. July 4 saw the election of a technocratic Labour administration which is likely to make the previous 14 years of Conservative ineptitude and betrayal seem like a golden age.
AWS makes strong case for its security advantages at re:Inforce
At re:Inforce 2024, AWS shared details of its secure by design measures to protect customer data. By David Vance, Senior Analyst Published: 21 Jun 2024 With the increasing number of security incidents and data breaches organizations continue to experience, infrastructure security needs to be a top priority.
Gestion des risques : 10 mises à jour de sécurité à retenir de la RSA Conference 2024 | LeMagIT
La conférence RSA, qui se tient chaque année au printemps à San Francisco, est l’une des plus grandes et des plus importantes conférences sur la sécurité au monde. Chaque année, un thème ou une tendance se démarque. Il n’est pas surprenant que l’un des thèmes prédominants cette année – après avoir émergé en 2023 – ait été l’IA (à noter également de larges discussions atour de la sécurité by design). Officiellement, 600 exposants ont participé à RSAC 2024.
10 risk-related security updates you may have missed at RSA
arthead - stock.adobe.com AI was a prominent theme at RSA Conference, but many security vendors also delivered risk-focused capabilities to help Infosec pros better manage their risk posture. By David Vance, Senior Analyst Published: 17 May 2024 The annual RSA Conference held in San Francisco every spring is one of the largest, most prominent security conferences in the world. And every year there’s one main theme or trend that stands out.
3 reasons Synopsys is selling its app security business
Synopsis is selling its application security business to a private equity firm. Analyst David Vance explains why, as well as what it means for the industry. By David Vance, Senior Analyst Published: 16 May 2024 Synopsys announced on May 6, 2024, that it is selling its application security business to private equity firms Francisco Partners and Clearlake Capital Group for $2.1 billion. The move was first mentioned during the company's fourth-quarter earnings call in November 2023.
Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi
Abstract Lyme disease is a tick-borne, multisystem infection caused by the spirochete, Borreliella burgdorferi. Although antibodies have been implicated in the resolution of Lyme disease, the specific B cell epitopes targeted during human infections remain largely unknown. In this study, we characterized and defined the structural epitope of a patient-derived bactericidal monoclonal IgG (B11) against Outer surface protein C (OspC), a homodimeric lipoprotein necessary for B.
What Next After Genocide-By-Proxy & The Murder Of Diplomacy? The Quest For Peace
ILANA believes that America’s open, even-energetic support for Israel’s genocide in Gaza is a defining event in the annals of American foreign policy, and that this failure is qualitatively different from blunders that went before. In its role in Gaza, Uncle Sam has finally achieved an official or formal inversion of all decent, universal values.
Australia - a global tyrant!
NEW! Many of us were shocked at the tyrannical behaviour of certain Australian politicians during Covid times. Turns out that the was just a prelude for the sort of global tyranny some of them want to exercise! Let me introduce you to Jacqui Lambie….she wants to imprison Elon Musk! BUY ME A COFFEE HERE AND SUPPORT MY WORK ON THIS PODCAST! DO JOIN MY SUBSTACK HERE! This podcast is sponsored by https://www.quantumhypno.co.uk/ Visits: 3
Iran Tries To Restore Balance; Israel Continues To Murder And Get Away With Murder
HARD TRUTH’S David Vance and ilana Mercer have a heated discussion about Iran’s April 13 & 14 response to Israel’s murder of senior commanders in Damascus, April 1. Ilana details Israel’s lengthy illegal, immoral and extra-judiciary assassination program https://www.ilanamercer.com/2020/01/u-s-globes-judge-jury-executioner/ against Iranian civilians and military for decades, coupled as it is with Israeli cyberterrorism ongoing against Iran’s infrastructure and state apparatus.
5 areas to help secure your cyber-risk management program
To meet the challenges of managing cyber-risk, organizations need to have a cyber-risk management plan in place. Look at five areas to better secure your organization's assets. By David Vance, Senior Analyst Published: 28 Mar 2024 It's important to first define cyber-risk in order to understand cyber-risk management and determine goals and needs for an effective management program.
Sexual Risk Behaviors Among the Transgender and Gender Diverse Populat
Background Sexual risk behaviors (SRB) is a term describing sexual behaviors that can lead to unwanted outcomes, such as sexually transmitted infections (STIs) or pregnancy. Yet, the exact behaviors assessed and included in this definition vary in research studies and clinical practice across populations. Transgender and gender diverse (TGD) adults are those who have a gender identity that is different from their sex assigned at birth.
Thou shalt NOT damage Satan.
In a new twist, a man is charged with a Hate Crime because he destroyed a shrine to Satan in the Iowa State Building! Please note that TICKETS for our next LIVE show in LONDON are now available here! This podcast is sponsored by
Hermetically Sealed Indictment Of The Jewish Taliban’s Mass Murder In Gaza
As always, HARD TRUTH’S David Vance and ilana Mercer arrive together at the truth about Gaza. Ilana says ( https://www.ilanamercer.com/2024/01/memory-indictment-todays-jewish-taliban-not-israel-grew/ ) that it is inarguable: The case against Israel’s murder spree in Gaza is ethically simple, and not within the realm of opinion. It is immutable, eternal truth that: Right and wrong are universal, not relative. There are no tribal privilege clauses: Like gentiles, Jews are prohibited from mass murder.
Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)
Abstract Camelid-derived, single-domain antibodies (VHHs) have proven to be extremely powerful tools in defining the antigenic landscape of immunologically heterogeneous surface proteins. In this report, we generated a phage-displayed VHH library directed against the candidate Lyme disease vaccine antigen, Outer surface protein A (OspA).
Cognitive criteria in HIV: greater consensus is needed - Nature Reviews Neurology
A recently published Consensus Statement by Sam Nightingale and colleagues (Nightingale, S. et al. Cognitive impairment in people living with HIV: consensus recommendations for a new approach. Nat. Rev. Neurol. 19, 424–433; 2023)1 proposes a new approach to classifying cognitive impairment in people living with HIV. Although we applaud the efforts of the authors, other considerations are needed to ensure earlier and more consistent diagnosis, prevention and enhanced patient care.
How To Defeat Hamas And Stop The Carnage In Gaza
HARD TRUTH sees David Vance and ilana Mercer catch up with each other three weeks into the Israel/Hamas catastrophe. Has Netanyahu desecrated the memory of the Oct. 7th martyrs and created new martyrs in Gaza, via his crude response to the Hamas massacre? Has Israel’s PM isolated Israel and squandered the sympathy toward the Jewish State, following Oct. 7? Ilana argues that needed was a smarter, more effective response that targets only the culprits of Oct. 7, not innocents.
Cognitive intra-individual variability in breast cancer survivors: A systematic review
References Ahles, T. A., Andreotti, C., & Correa, D. D. (2015). Neuropsychological impact of cancer and cancer treatments. In J. C. Holland, W. S. Breitbart, P. B. Jacobsen, M. S. Lederberg, M. J. Loscalzo, & R. T. McCorkle (Eds.), Psycho-Oncology (3rd ed., pp. 311–319). Oxford University Press. (Open in a new window)Google Scholar Ahles, T. A., Saykin, A. J., McDonald, B. C., Furstenberg, C. T., Cole, B. F., Hanscom, B. S., Mulrooney, T. J., Schwartz, G. N., & Kaufman, P. A. (2008).
Hamas, Israel And The Anatomy Of State Treason
HARD TRUTH with David Vance and ilana mercer deconstructs Hamas's low-tech invasion into southern Israel and the massacre of hundreds of its civilians. Witnessed in Israel on October 7 was the forsaking by the State of its most elementary—and only—obligations to the citizenry: Defend their natural rights to life, liberty and property.
McDowell et al v. The Board of Trustees for Perry Township, Stark County, Ohio et al
Plaintiff: F. Dyann McDowell and Training Marbles, Inc. Defendant: The Board of Trustees for Perry Township, Stark County, Ohio and Michael T.
Stephen Nolan becomes the biggest story in the Country!
BBC NI ”Star” Stephen Nolan hosts several TV and Radio shows and boasts that his show is ”the biggest in the country”. So I am sure he will use his platform to address the lurid allegations made against him in the Irish News and repeated in the Daily Mail…. Find a whole lot more at https://davidvance.net
Influence of HIV infection on cognition and overall intelligence in HIV-infected individuals: advances and perspectives
Introduction Despite decades of massive financial and intellectual investment, human immunodeficiency virus (HIV) infection remains a global public health burden today.
Low levels of peripheral blood activated and senescent T cells characterize people with HIV-1-associated neurocognitive disorders
Introduction Neurocognitive impairment (NCI) may be observed in 20 to 30%, and up to 60% of efficiently treated people living with HIV (PLWH) (1, 2). We recently published an almost 75% increase in the risk of HIV-associated neurocognitive disorder (HAND) in ageing PLWH after adjustment on age, sex, education, comorbidities, depression and social confounding factors (2). In the course of HIV infection under treatment, NCI may be fuelled by various etiological factors.
Sunak and Hunt will wipe out the Conservatives in 2024.
It is reported that Prime Minister Sunak and his henchman Jeremy Hunt are ”prepared to risk a recession” to get interest rates down, even as they put interest rates up! Listen, the Party is dead and it will get a burial next year at the General Election. Find a whole lot more at https://davidvance.net
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