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Articles by David Walzik
Acute exercise rewires the proteomic landscape of human immune cells - Nature Communications
Abstract The positive effect of exercise on the immune system is widely acknowledged, but the molecular response of immune cells to exercise remains largely unknown. Here, we perform mass-spectrometry-based proteomic analysis on peripheral blood mononuclear cells (PBMC) at a depth of >6000 proteins.
Acute exercise rewires the proteomic landscape of human immune cells
The authors have declared no competing interest. DRKS00017686 This study received internal funding by the German Sport University Cologne. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee/IRB of the German Sport University Cologne gave ethical approval for this work.
Molecular insights of exercise therapy in disease prevention and treatment - Signal Transduction and Targeted Therapy
Abstract Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases, the underlying biological mechanisms have not been fully elucidated. Several exercise benefits have been attributed to signaling molecules that are released in response to exercise by different tissues such as skeletal muscle, cardiac muscle, adipose, and liver tissue.
What dictates tumour cell sensitivity to exercise? - Nature Reviews Immunology
With great interest, we have read the Perspective article by Fiuza-Luces et al.1 on exercise-induced anticancer immunity. The authors highlighted a well-known theory that exercise-induced immunosurveillance — with a prominent role for natural killer (NK) cells — may underpin the anticancer effects of physical activity in humans.
Acute exercise increases systemic kynurenine pathway metabolites and activates the AHR in human PBMCs
Abstract The kynurenine pathway of tryptophan degradation generates several metabolites such as kynurenine or kynurenic acid that serve as endogenous ligands of the aryl hydrocarbon receptor (AHR). Due to its distinct biological roles particularly modulating the immune system, the AHR is a current therapeutic target across different inflammation-related diseases.
Cellular immune response to acute exercise: Comparison of endurance and resistance exercise
ORIGINAL ARTICLE Philipp Zimmer Corresponding Author E-mail address: philipp.zimmer@tu-dortmund.de Department of “Performance and Health (Sports Medicine), Institute of Sport and Sport Science, Technical University Dortmund, Dortmund, Germany shared last authorship Corresponding author: Prof.
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