Alcohol withdrawal during adolescence is associated with profound neurobehavioral and neurochemical disturbances. This study investigated the protective effects of niacin in adolescent rats exposed to escalating ethanol concentrations from postnatal day 24 to 60. Niacin (25 or 50 mg/kg, i.p.) was administered once daily throughout the ethanol exposure period. Following ethanol withdrawal, behavioral assessments and biochemical analyses of the prefrontal cortex were conducted.
