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Articles by De Groef
Exploring quality of life and physical-physiological characteristics in obese patients with and without lipedema: insights from the LipObes study
Background Lipedema is a prevalent chronic condition in women, characterized by a painful and symmetrical accumulation of adipose tissue primarily in the lower limbs. Its diagnosis is based on specific clinical characteristics; however, these characteristics lack robust scientific validation. Furthermore, lipedema is frequently misdiagnosed as obesity. This study aims to compare quality of life and physical and psychological characteristics between patients with obesity with and without lipedema.
A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome - Acta Neuropathologica Communications
All experiments were performed using Wfs1∆exon8 mice (Wfs1 KO mice) and wild type littermates (129S6/SvEvTac and C57BL/6 mixed background). This mouse model was originally created by Luuk et al. and has a disrupted exon 8 in the Wfs1 gene [44]. Mice were bred under standard laboratory conditions and had free access to food and water. Mice of both sexes were used, at the age of 3 months (± 1 week), 4.5 months (± 1 week), 6 months (± 2 weeks) or 7.5 months (± 2 weeks).
Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons - Acta Neuropathologica Communications
Animals All experiments were performed using a combination of male and female 8–12-week-old mice of following strains: C57BL/6 wild-type, Lyz2-GFP [90], Cx3cr1CreER [91], R26-YFP [92] and Ccr2−/− [45] mice, as outlined in Additional File 7: Table S1. All animal experiments were approved by the Institutional Ethical Committees for Animal Experimentation of KU Leuven and the Vrije Universiteit Brussel and were conducted in strict accordance with the European and Belgian legislation.
EffEx-HN trial: study protocol for a randomized controlled trial on the EFFectiveness and feasibility of a comprehensive supervised EXercise program during radiotherapy in Head and Neck cancer patients on health-related quality of life | Trials | Full Tex
The SPIRIT guidelines were used [15]. The recruitment of the clinical trial started in January 2022 at the department of Radiation-Oncology of the University Hospitals in Leuven (Belgium). The supervised exercise sessions of the intervention group take place in the exercise room of the department of Physical Medicine and Rehabilitation of the University Hospitals in Leuven (Belgium). A flowchart of the EffEx-HN Trial is provided in Table 1.
On the other end of the line: extracellular vesicle-mediated communication in glaucoma
Cristiano Lucci1 and Lies De Groef1* 1Cellular Communication and Neurodegeneration Research Group, Department of Biology, Leuven Brain Institute, KU Leuven, Belgium The final, formatted version of the article will be published soon. Receive an email when it is updated In the last decade, extracellular vesicles (EVs) have emerged as a promising field of research due to their ability to participate in cell-to-cell communication via the transfer of their very diverse and complex cargo.
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