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Articles by De Maleki
Exercise Modulates Microbial Metabolites and Induces Stromal Remodeling in Pancreatic Cancer Available to Purchase
RNA-seq and 16S rRNA-seq data have been deposited in the NCBI SRA under BioProject PRJNA1514747 (GSE344191) and PRJNA1292859. Processed data are available from the corresponding author upon a reasonable request. All other raw data are available upon request to the corresponding author.
Exercise Modulates Microbial Metabolites and Induces Stromal Remodeling in Pancreatic Cancer Available to Purchase
Exercise induces a variety of changes in the tumor microenvironment, with beneficial effects in several tumor types. However, a better understanding of the clinical effects of exercise and mediating mechanisms is needed to maximize the utility of exercise for patients. In this study, we analyzed tumors from patients with pancreatic ductal adenocarcinoma (PDAC) in the PancFit trial and identified an exercise-induced reduction in cells expressing α-smooth muscle actin (αSMA).
Aerobic Exercise Activates S1PR1 Signaling in Tumor Endothelial Cells to Promote Vascular Function in Pancreatic Cancer Available to Purchase
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Exercise modulates microbial metabolites and induces stromal remodeling in pancreatic cancer Available to Purchase
Exercise induces a variety of changes in the tumor microenvironment with beneficial effects in several tumor types. However, a better understanding of the clinical effects of exercise and mediating mechanisms is needed to maximize the utility of exercise for patients. In this study, we analyzed tumors from pancreatic ductal adenocarcinoma (PDAC) patients in the PancFit trial and identified an exercise induced reduction in cells expressing alpha smooth muscle actin (αSMA).
Aerobic Exercise Activates S1PR1 Signaling in Tumor Endothelial Cells to Promote Vascular Function in Pancreatic Cancer Available to Purchase
Pancreatic ductal adenocarcinoma (PDAC) is characterized by high resistance to anticancer therapies, which is caused in part by hypovascularization and dysfunctional vessels that inefficiently deliver chemotherapy. Exercise has been shown to improve tumor vascular function and chemotherapy efficacy in preclinical models. Uncovering the mechanism by which exercise modifies tumor vasculature could help identify potential strategies to improve drug delivery.
Aerobic Exercise Activates S1PR1 Signaling in Tumor Endothelial Cells to Promote Vascular Function in Pancreatic Cancer Available to Purchase
Pancreatic ductal adenocarcinoma (PDAC) is characterized by high resistance to anti-cancer therapies, which is caused in part by hypo-vascularization and dysfunctional vessels that inefficiently deliver chemotherapy. Exercise has been shown to improve tumor vascular function and chemotherapy efficacy in preclinical models. Uncovering the mechanism by which exercise modifies tumor vasculature could help identify potential strategies to improve drug delivery.
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