1 Introduction Common variable immunodeficiency (CVID) is the most common primary immunodeficiency in adulthood and is characterized by a defective B cell differentiation, impaired antibody secretion and recurrent bacterial infections. More than 30% of patients also suffer from non-infectious comorbidities attributed to immune dysregulation. These have become the leading cause of death in CVID since immunoglobulin replacement therapy is insufficient to prevent or control their complications.
