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de Steenwinkel

As seen in: Oxford Academic, American Society for Microbiology (ASM)
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Articles by de Steenwinkel

Relative contributions of the novel diarylquinoline TBAJ-876 and its active metabolite to the bactericidal activity in a murine model of tuberculosis

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By ten Kate, de Steenwinkel, Jurriaan E M
| Oxford Academic Verified
TBAJ-876 is a next-generation diarylquinoline. In vivo, diarylquinoline metabolites are formed with activity against Mycobacterium tuberculosis. Species-specific differences in parent drug-to-metabolite ratios might impact the translational value of animal model-based predictions. This study investigates the contribution of TBAJ-876 and its major active metabolite, TBAJ-876-M3 (M3), to the total bactericidal activity in a mouse tuberculosis model.
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Higher Dosing of Rifamycins Does Not Increase Activity against Mycobacterium tuberculosis in the Hollow-Fiber Infection Model

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By de Steenwinkel
| American Society for Microbiology (ASM)
Clinical Therapeutics E. D. Pieterman, S. van den Berg, A. van der Meijden, E. M. Svensson, H. I. Bax, J. E. M. de Steenwinkel DOI: 10.1128/AAC.02255-20 ABSTRACT Improvements in the translational value of preclinical models can allow more-successful and more-focused research on shortening the duration of tuberculosis treatment. Although the hollow-fiber infection model (HFIM) is considered a valuable addition to the drug development pipeline, its exact role has not been fully determined yet.
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