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Dekai Liu

As seen in: Nature, Frontiers in Immunology
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Articles by Dekai Liu

The genomic and proteomic landscape of Chinese familial prostate cancer reveals unique mutational signatures and targetable pathways

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By Yuhao Zhang, Qifeng Zhong, Yumiao Xu, Jungang Zhao, Lijie You, Wenyi Zhao, Jingqi Zhou, Yiwei Jiang, Yutao Zhang, Jili Wang, Zhan Zhou, Guoping Ren, Yichun Zheng, Dekai Liu, Ruiying Kong, Minjing Shi, Lianghao Lin
| Nature Verified
Abstract Prostate cancer in Chinese men presents distinct molecular features compared with Western populations, yet the genomic basis of familial cases remains poorly defined. Here, we present the first integrated genomic and proteomic profile of 108 Chinese familial prostate cancers versus matched sporadic controls.
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Spatial and single-cell insights into the prostate cancer microenvironment: overcoming immunotherapy resistance through multidimensional strategies

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By Dekai Liu, Junliang Tang, Yiwei Jiang, Jungang Zhao, Junxiao Shen, Lijie You, Yichun Zheng
| Frontiers in Immunology
Abstract Despite breakthroughs in immune checkpoint inhibitors (ICIs) across various malignancies, prostate cancer (PCa), particularly metastatic castration-resistant prostate cancer (mCRPC), has shown limited responses to ICIs. This pervasive primary resistance is fundamentally driven by the canonically “immune-cold” and highly immunosuppressive tumor microenvironment (TME) of PCa. Propelled by recent advancements in single-cell RNA sequencing and spatial transcriptomics, this review...
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