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Why was the study undertaken? Cutaneous leishmaniasis (CL) is endemic in parts of Southern Europe and is increasingly being reported in formerly non-endemic regions of Central Europe. Several systemic treatments for CL exist, with pentavalent antimonials (e.g., meglumine antimoniate (MA)) having been used as standard care for many decades despite limited evidence. This study was undertaken to systematically synthesize and compare the efficacy of currently used systemic monotherapies for CL.
Discussion This is the first comprehensive synthesis and estimation of the physical health burden associated with frequent serious MHDs in Europe. We identified elevated risks for almost all available PHC categories based on existing literature, although some of these did not reach statistical significance.
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