Loading metrics Open Access Peer-reviewed Research Article Edward D. Bonnevie, Devis Galesso, Cynthia Secchieri, Lawrence J. Bonassar Edward D. Bonnevie, Devis Galesso, Cynthia Secchieri, Lawrence J. Bonassar Published: May 10, 2019 https://doi.org/10.1371/journal.pone.0216702 Figures Abstract Hyaluronic acid injections have been a mainstay of arthritis treatment for decades. However, much controversy remains about their clinical efficacy and their potential mechanism of action.