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Cytopathology and Prognostic Accuracy of 15-GEP/PRAME: The Collaborative Ocular Oncology Group Study 2 Key Points Question Is confirmatory cytopathology associated with the prognostic accuracy of a 15-gene expression profile (15-GEP)/Preferentially Expressed Antigen in Melanoma (PRAME) classifier in predicting metastatic uveal melanoma risk?
Importance Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis. Objective To determine whether any clinicopathologic factors provide independent prognostic information that may enhance the accuracy of the GEP classification.
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