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Articles by Diana Fleming
Hidden Tauopathy: Autopsy Data Reveal Progressive Supranuclear Palsy Is Far More Common Than Thought
Progressive supranuclear palsy, a relentless brain disease first described in the 1960s by neurologists Steele, Richardson, and Olszewski, has long been considered a rare disorder, with prevalence estimates typically hovering around one in ten thousand people. A sweeping new analysis of autopsy data from 38 U.S. Alzheimer’s Disease Research Centers, published in Acta Neuropathologica, now suggests that this reputation for rarity may be profoundly wrong. The study, led by Benjamin J.
Massive Analysis of 173 Trials Reveals How Exercise Type and Dose Shape Motor Symptoms in Parkinson’s Disease
For millions of people living with Parkinson’s disease, the question of which exercise to do—and how much of it—has long been a source of confusion. Clinicians can choose from a bewildering menu of options: treadmill walking, resistance training, dance, tai chi, yoga, boxing, aquatic therapy, and more. Each has its champions, its small trials, and its enthusiastic anecdotes.
Why Some Neurons Survive: Identity Maintenance May Set the Threshold of Neurodegeneration
Neurodegenerative diseases are strikingly selective. In Parkinson’s disease, dopamine-producing neurons in the substantia nigra pars compacta die early and extensively, while their close neighbors in the ventral tegmental area, which share the same neurotransmitter and arise from related developmental programs, survive for far longer.
Four Weeks of Intensive Inpatient Rehabilitation Lifts Quality of Life in Parkinson’s Disease
Parkinson’s disease is usually described in terms of its most visible features: the resting tremor, the slowed movements, the stiffness that gradually reshapes the way a person walks and moves. Yet for many patients, it is the less obvious burdens — pain, fatigue, sleep disturbance, mood disorders and cognitive decline — that erode day-to-day life most severely.
Astrocytes Drive the Mitochondrial Traffic Jams Behind a Common Form of ALS
In the crowded world of neurodegeneration research, motor neurons have long occupied the spotlight in amyotrophic lateral sclerosis, the relentless disease that strips people of the ability to move, speak and eventually breathe. But a new study published in Nature Neuroscience argues that the true puppet masters of one of the disease’s most damaging cellular defects may be sitting quietly beside those neurons. A team led by Maria Stavrou and Bhuvaneish T.
Antidepressants May Blur the Warning Sign Hidden in Dream-Enacting Sleep
Every night, in the deepest stretch of dreaming sleep, the healthy brain performs a remarkable trick: it switches off the body. During rapid eye movement, or REM, sleep, a network of brainstem circuits actively paralyzes nearly every muscle below the head, pinning the dreamer in place while the mind races through vivid hallucinations.
Silver steps are just as important as your first step
Remember watching a child learn to take their first step? Taking that first step is just as important as every step taken throughout life, and the more you take, the more you benefit! What’s really cool — even the smallest amount of physical activity benefits our health. What is the best physical activity you can do to improve or maintain your health? The answer is simple — the kind you enjoy doing. If you don’t enjoy it, you won’t do it long term.
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