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Abstract Background: Tuberculosis (TB) remains one of the world’s deadliest infectious diseases and continues to be hindered by poor public awareness, stigma, and misinformation, all of which can contribute to delayed diagnosis, ongoing transmission, and poor treatment adherence. In low-incidence settings, limited public attention to TB may further reduce basic knowledge and represent an additional barrier to control efforts.
Abstract The tuberculosis (TB) lesion is a complex structure, contributing to the overall spectrum of TB. We characterise, using RNA sequencing, 44 fresh human pulmonary TB lesion samples from 13 TB individuals (drug-sensitive and multidrug-resistant TB) undergoing therapeutic surgery. We confirm clear separation between the TB lesion and adjacent non-lesional tissue, with the lesion samples consistently displaying increased inflammatory profile despite heterogeneity.
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