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Articles by Diffusion Imaging

An Investigation of Corticospinal Tract Microstructural Integrity in ARSACS Using a Profilometry MRI Analysis: Results From the PROSPAX Study

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By Alessandra Scaravilli, Diffusion Imaging, Gaia Mari, Ilaria Gabusi
| Wiley Online Library Verified
ARSACS Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay CST corticospinal tract dMRI diffusion MRI MCP middle cerebellar peduncles SARA Scale for the Assessment and Rating of Ataxia SPAX spastic ataxia SPRS Spastic Paraplegia Rating Scale TPF transverse pontine fibers WM white matter 1 Introduction Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS, MIM 270550) is an early-onset recessive form of spastic ataxia (SPAX), caused by mutations in the SACS gene [1].
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Gradient of microstructural damage along the dentato‐thalamo‐cortical tract in Friedreich ataxia

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By Sirio Cocozza, Diffusion Imaging, Sara Bosticardo, Matteo Battocchio
| Wiley Online Library Verified
Introduction Friedreich ataxia (FRDA) is one of the most common inherited ataxias, most frequently caused by a homozygous GAA triplet-repeat expansion in the first intron of the frataxin gene (FXN).1 The neurological features of FRDA include progressive cerebellar dysfunction with limb and gait ataxia, dysarthria, oculomotor disturbances, sensory deafferentation, and reduced tendon reflex responses.2 In FRDA, central nervous system pathology primarily impacts the cerebellum and spinal cord.
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An MRI evaluation of white matter involvement in paradigmatic forms of spastic ataxia: results from the multi-center PROSPAX study - Journal of Neurology

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By van de Warrenburg, Filippo Maria, Diffusion Imaging, La Piana
| link.springer.com
Abstract Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) and Spastic Paraplegia Type 7 (SPG7) are paradigmatic spastic ataxias (SPAX) with suggested white matter (WM) involvement. Aim of this work was to thoroughly disentangle the degree of WM involvement in these conditions, evaluating both macrostructure and microstructure via the analysis of diffusion MRI (dMRI) data.
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Evaluation of tractography-based myelin-weighted connectivity across the lifespan

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By Translational Imaging, Biomedical Engineering, ASG Superconductors S.p.A, Diffusion Imaging
| Frontiers
Sara Bosticardo1, 2* Simona Schiavi1, 3 Sabine Schädelin2 Matteo Battocchio1, 4 Muhamed Barakovic2, 5 Po-Jui Lu2, 5 Matthias Weigel2, 5 Lester Melie-Garcia2, 5 Cristina Granziera2, 5 Alessandro Daducci1 1Diffusion Imaging and Connectivity Estimation (DICE) Lab, Department of Computer Science, University of Verona, Italy 2Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Switzerland 3ASG...
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