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Abstract Efficient RNA production is essential for therapeutic applications. Currently, mRNA is generated by in vitro transcription with RNA polymerases at a constant temperature. The success of these transcriptions depends on various factors including sequence composition and size. Sometimes, especially for long RNAs, achieving efficient transcript yields are challenging. We developed a novel approach by incorporating a high-temperature denaturation step.
Abstract Mechanisms that trigger Aβ production in sporadic Alzheimer's disease are still obscure. We recently reported the expression of a human circular RNA (circAβ-a) encoded Aβ peptide precursor variant (Aβ175). Presently, we demonstrated that AAV9 virus-expressed circAβ-a gave rise to extensive extracellular Aβ plaque depositions and microglial activation in mouse brain; this recapitulates critical pathogenic hallmarks within a sporadic AD mouse model.
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