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ORIGINAL RESEARCH article Front. Immunol. Sec. Alloimmunity and Transplantation Advances in MICA Genotyping: Characterization of 406 Novel Alleles and their Frequencies in Multiple Populations Provisionally accepted 1DKMS Life Science Lab, Dresden, Germany 2DKMS Group, Tübingen, Germany The final, formatted version of the article will be published soon.
1 Introduction The MICA (MHC class I polypeptide-related sequence A) gene is located on chromosome 6 within the human major histocompatibility (MHC) complex, between HLA-B and MICB (1). Despite their high structural similarity to the classical human leukocyte antigen (HLA) genes, MICA and MICB (MICA/B) do not present peptides.
1. Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the treatment of choice for some forms of leukemia and other life-threatening conditions (1–3). Currently, more than 50,000 allo-HSCT procedures are performed per annum worldwide (4). Except for haploidentical donors, allo-HSCT donors need to be HLA-matched at high resolution to avoid severe transplant-related complications, such as graft-versus-host disease (5, 6).
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