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1 Introduction GNE myopathy is a rare autosomal recessive muscular disorder characterized by slow progressive muscle weakness of distal muscles [1-3]. The GNE gene encodes for UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, an essential bifunctional enzyme for sialic acid biosynthesis.
1 Introduction Bone is the most frequent metastatic site in patients with advanced prostate cancer (PCa). The presence of bone lesions contributes significantly to the decline in patient quality of life and increased mortality. These lesions result in weakened and brittle bones leading to fractures. Currently available treatments for such patients are mostly palliative and not curative.
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