Abstract: Liposomes, as highly efficient bioactive substance delivery systems, are often limited in their applications due to poor stability and insufficient targeting capabilities. In this study, stearamine was employed as a cationic inducer to prepare cationic liposomes (Lip). Utilizing electrostatic deposition technology, hyaluronic acid (HA), fucoidan (Fuc), chondroitin sulfate (CS), and carboxymethyl chitosan (CMCS) were deposited onto the liposome surface via electrostatic deposition.