Based on a relatively large-scale population-based cross-sectional study, it was found that MetS and its components (e.g., overweight, hypertension and dyslipidemia) were associated with the prevalence of radiographic knee OA in a Chinese population with adjustment of a number of confounding factors. With the accumulation of MetS components, the prevalence of knee OA increased. The positive association remained significant after adding hsCRP into the multivariable model.