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Articles by Dongdong Su
The metabolic-inflammatory axis in chronic heart failure: integrating the NLR and TyG index for recent-onset atrial fibrillation prediction via machine learning and mediation analysis
Abstract Introduction: Recent-onset atrial fibrillation (AF) is a common complication of chronic heart failure (CHF), potentially involving both inflammatory and metabolic dysregulation. This study aimed to develop and externally validate an interpretable machine learning (ML) model for predicting recent-onset AF in patients with CHF and to explore the relationships among inflammatory dysregulation, metabolic dysregulation, and recent-onset AF.
A multi-level dynamic sample augmentation and heterogeneous feature fusion framework for intelligent intrusion detection
Abstract This paper proposes a hybrid intrusion detection framework that integrates dynamic sample augmentation and heterogeneous feature fusion to address class imbalance and temporal complexity in network traffic. At the data level, an ADASYN–FLS–SMOTEBoost strategy combines adaptive oversampling with Focal Loss–Softmax (FLS) weighting to generate more representative minority samples.
Cyclodextrin-Based Pickering Emulsion Significantly Increases 6-Gingerol Loading Through Two Different Mechanisms: Cyclodextrin Cavity and Pickering Core
Open AccessArticle by Xingran Kou 1,2,*, Dongdong Su 2, Jingzhi Zhang 2, Fei Pan 3, Jiamin Zhu 2, Qingran Meng 2 and Qinfei Ke 1,2,* 1 Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China 2 Collaborative Innovation Center of Fragrance Flavour and Cosmetics, School of Perfume and Aroma Technology (Shanghai Research Institute of Fragrance & Flavour Industry), Shanghai Institute of Technology, Shanghai 201418,...
Extended Pantograph-Catenary Arc Modeling and an Analysis of the Vehicular-Grounding Electromagnetic Transients of Electric Multiple Units
1. Introduction High-speed railways (HSRs) have been developed rapidly in China, with a length of 41,000 km and a national railway network density of 156.7 km/10,000 km2. The pantograph–catenary (PC) connection is still the bottleneck limiting HSR development. As electric multiple units (EMUs) operate, a detachment arc often takes place between the pantograph and the contact wire due to track irregularities and PC vibration.
Recent Progress in Fluorescent Probes for the Detection and Research of Hydrogen Sulfide in Cells
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Peptide and Protein Modified Metal Clusters for Cancer Diagnostics
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A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2
Tumor initiating cells (TIC) are resistant to conventional anticancer therapy and associated with metastasis and relapse in cancer. Although various TIC markers and their antibodies have been proposed, it is limited to the use of antibodies for in vivo imaging or treatment of TIC. In this study, we discovered heme oxygenase 2 (HMOX2) as a novel biomarker for TIC and developed a selective small molecule probe TiNIR (tumor initiating cell probe with near infrared).
Frontispiece: Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate
Frontispiece Frontispiece: Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate Dr. Jung‐Yeol Lee Department of Chemistry, Pohang University of Science and Technology, Pohang, 37673 Korea Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore, 138667 Singapore Present address: New drug discovery center, DGMIF, Daegu, 41061 Korea Search for more papers by this author Xiao Liu Department of Chemistry, Pohang University of Science and...
Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate
Communication Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate Dr. Jung‐Yeol Lee Department of Chemistry, Pohang University of Science and Technology, Pohang, 37673 Korea Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore, 138667 Singapore Present address: New drug discovery center, DGMIF, Daegu, 41061 Korea Search for more papers by this author Xiao Liu Department of Chemistry, Pohang University of Science and Technology,...
De Novo Design of Chemical Stability Near-Infrared Molecular Probes for High-Fidelity Hepatotoxicity Evaluation In Vivo
Dan Cheng†, Juanjuan Peng‡, Yun Lv†, Dongdong Su§ , Dongjie Liu∥, Mei Chen∥, Lin Yuan*† , and Xiaobing Zhang† † State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 , P. R. China ‡ State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198 , P. R.
Visualization of Oxidative Injury in the Mouse Kidney by Selective Superoxide Anion Fluorescent Probes
Drug-induced acute kidney injury (AKI), caused by renal drug metabolism, has been regarded as a main problem in clinical pharmacology and practice. However, due to the lack of effective biomarkers and noninvasive real-time tools, the early diagnosis of drug-induced AKI is still a crucial challenge. Superoxide anion (O2•-), the preliminary reactive oxidative species, is closely related to drug-induced AKI.
Detection of analytes in mitochondria without interference from other sites based on an innovative ratiometric fluorophore
Mitochondria are vital organelles that not only produce cellular energy but also participate in many biological processes. Recently, various fluorescent probes have been developed for mitochondria imaging. However, due to the lack of suitable dyes or strategies, most reported mitochondrial targeting probes are difficult to prove whether the analytes they detected are from mitochondria. In addition, the positive charge on the mitochondrial probes can seriously effect the mitochondrial environment.
A palette of background-free tame fluorescent probes for intracellular multi-color labelling in live cells
Multi-color labelling technique for visualizing multiple intracellular apparatuses in their native environment using small fluorescent probes remains challenging. This approach requires both orthogonal and biocompatible coupling reactions in heterogeneous biological systems with minimum fluorescence background. Here, we present a palette of BODIPY probes containing azide and cyclooctyne moiety for copper-free click chemistry in living cells.
A New Approach for Turn-on Fluorescence Sensing of L-DOPA
L. Wang, D. Su, S. Berry, J. Y. Lee and Y. Chang, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC07640A If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
Motion-induced change in emission (MICE) for developing fluorescent probes
The need for detecting and labelling environmentally and biologically important analytes has driven considerable research efforts in developing fluorescent probes. During the sensing process, molecular motions (i.e., molecular rotations or vibrations) of a flexible fluorescent probe can be significantly altered by its embedding micro-environment or analyte, thereby leading to substantial changes in readout signals.
Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells
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