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Articles by Dongyang Han
Ferricyanide-mediated direct ligation of peptide hydrazides in neutral water
Abstract Hydrazide-based native chemical ligation has emerged as one of the most widely used methods in modern chemical protein synthesis, but its traditional two-step, dual-environment workflow complicates operations and limits small-scale reactions. Here we present a ferricyanide-mediated system that enables chemoselective activation of peptide hydrazides and their ligation with N-terminal cysteine peptides in a single neutral buffer.
Correction to “An Integrated Solubilizing-Tag-Free Strategy for Chemical Synthesis of Mirror-Image Interleukin-6” Click to copy article link Article link copied!
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Pressure-Induced Enhancement of Proton Conduction across MOF Grain Boundaries
Pressure-Induced Enhancement of Proton Conduction across MOF Grain Boundaries The proton exchange membrane is the core of a fuel cell, with its performance limited by proton transport efficiency. Metalorganic frameworks (MOFs) have shown promise as proton conductors due to their adjustable porosity, but the grain boundaries of polycrystalline MOFs impede proton transport.
The Role and Phagocytic Mechanisms of Alveolar Macrophages in Inflammatory Responses Induced by Diesel Exhaust Particles
Ecotoxicology and Public HealthJuly 16, 2025 Dongyang Han Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China Renzhen Peng Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China Bin Pan Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Pharmacy,...
Temporary Structural Supports for Chemical Protein Synthesis
Conflict of Interests The authors declare no conflict of interest. References 1, in Advances in Enzymology – and Related Areas of Molecular Biology (Ed: F.F. Nord), Wiley, John Wiley & Sons, Inc., 1969, pp. 221–296, https://doi.org/10.1002/9780470122778.ch6. 2, , , , Science 1994, 266, 776–779. 3, , , , , , , , Angew. Chem. Int. Ed. 2011, 50, 7645–7649. 4, , , , , Nat. Protoc. 2013, 8, 2483–2495. 5, , , Natl. Sci. Rev. 2016, 3, 107–116. 6, , , ACS Cent. Sci. 2024, 10, 1442–1459. 7, , Angew. Chem. Int.
Temporary Structural Supports for Chemical Protein Synthesis
The range of functional proteins that can be prepared by chemical protein synthesis includes those bearing complex modifications and incorporating D-amino acids, and exceeds what can be accessed by biological means, but the technique is still limited by the unfavorable solution behavior of many synthetic protein intermediates in buffer, leading to inefficient ligation, purification, and in vitro folding.
Superfast Protein Desulfurization Triggered by Low‐Energy Visible Light
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Efficient chemical synthesis of mirror-image DNA polymerase Dpo4 assisted by one-pot multi-segment condensation
Efficient chemical synthesis of mirror-image DNA polymerase Dpo4 assisted by one-pot multi-segment condensation The mirror-image DNA polymerase Dpo4 is a valuable enzymatic tool in biomedical research; however, its chemical synthesis has been hindered by low efficiency. Here, we describe an efficient chemical synthesis of D-Dpo4 using a one-pot multi-segment condensation strategy, which was achevied by Fmoc-masked peptide thioester.
Forests | Free Full-Text | Improving Pinus densata Carbon Stock Estimations through Remote Sensing in Shangri-La: A Nonlinear Mixed-Effects Model Integrating Soil Thickness and Topographic Variables
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Fire | Free Full-Text | Optimization of the Monitoring of Coal Spontaneous Combustion Degree Using a Distributed Fiber Optic Temperature Measurement System: Field Application and Evaluation
4. Application 4.1. Field Temperature Measuring Design The Wangyun Coal Mine, located in Shanxi Province, China, has an annual output of 1.8 million tons. Currently, the 15th coal seam is being mined, with a thickness of 4.7 m and an oxygen absorption capacity of 0.84 cm3/g, classified as type II spontaneous combustion coal seam. The cut length of the 15106 working face currently being mined is 180 m.
Comparative Analysis of Gas Adsorption and Diffusion Characteristics of the Coal Matrix under Constant Pressure and Constant Volume Conditions
Research coal particle gas diffusion law is of great significance for coal and gas comining, while the coal particle adsorption diffusion experiment is divided into two models: constant pressure and constant volume. It is worth exploring which model is more scientific in engineering applications. In this work, two diffusion models of constant pressure and constant volume were proposed based on the theory of the density gradient of free gas.
A Modified Method for Transient Transformation via Pollen Magnetofection in Lilium Germplasm
1. Introduction Plant genetic transformation is an important pathway to improve plant yield, quality, and tolerance to abiotic/biotic stress [1]. Plant transformation is a complex process that involves the preparation of explants, delivery of genes of interest into plant cells via Agrobacterium- or biolistic-mediated methods, selection and regeneration of transgenic plants, and verification of gene integration into the genome through molecular methods.
Ecological Water Requirement of Vegetation and Water Stress Assessment in the Middle Reaches of the Keriya River Basin
3. Results 3.1. Verification of the Rationality of the Results Evapotranspiration has ceased to be a fixed observation item of the local meteorological observatory in the study area since 2020. Considering the lack of measured data, we selected the evapotranspiration calculated by the Penman–Monteith formula suggested by the Food and Agriculture Organization of the United Nations (FAO) as the true value.
Organic Semiconducting Nanoparticles for Biosensor: A Review
Abstract : Highly bio-compatible organic semiconductors are widely used as biosensors, but their long-term stability can be compromised due to photo-degradation and structural instability. To address this issue, scientists have developed organic semiconductor nanoparticles (OSNs) by incorporating organic semiconductors into a stable framework or self-assembled structure. OSNs have shown excellent performance and can be used as high-resolution biosensors in modern medical and biological research.
Performance enhancement of p-Si/n-ZnGa2O4 heterojunction solar-blind UV photodetector through interface engineering
Performance enhancement of p-Si/n-ZnGa2O4 heterojunction solar-blind UV photodetector through interface engineering Dongyang Han, Ke-Wei Liu, Jialin Yang, Xing Chen, Binghui Li, Lei Liu and Dezhen Shen Abstract Interface engineering is an effective way to improve the performance of heterojunction photodetectors (PDs).
Baseline concentration of misfolded α‐synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease
The prognostic significance of misfolded α‐synuclein aggregates in Parkinson's disease has not been well investigated. The aim of this study was to reveal the relationship between misfolded α‐synuclein aggregate concentration in cerebrospinal fluid and cognitive decline risk in Parkinson's disease. A total of 278 patients with Parkinson's disease were retrospectively included. They were diagnosed between 2011 and 2013. The end point was 2016, and the follow‐up period was 54.3 ± 10.0 months.
Baseline concentration of misfolded α‐synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease
Background The prognostic significance of misfolded α‐synuclein aggregates in Parkinson's disease has not been well investigated. The aim of this study was to reveal the relationship between misfolded α‐synuclein aggregate concentration in cerebrospinal fluid and cognitive decline risk in Parkinson's disease. Methods A total of 278 patients with Parkinson's disease were retrospectively included. They were diagnosed between 2011 and 2013.
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