Abstract Introduction: Fecal calprotectin (FC) results may be unavailable during assessment of inflammatory or ulcerative intestinal lesions. We assessed FC documentation and developed a diagnostic prediction model using endoscopic features and blood-derived inflammatory indices for ulcerative colitis (UC). Methods: We retrospectively included 655 patients from four centers. Four prespecified logistic models were compared in complete cases (N = 455; 103 UC cases).