We use our muscles every day. When we walk or exercise, we create small tears that damage them. Luckily, skeletal muscles have an extraordinary ability to self-regenerate thanks to skeletal muscle stem cells called satellite cells. These cells, which surround muscle fiber (myofibers) at a quiescent state, have the capacity to activate and proliferate after muscle strain or injury and repair the injured myofibers, or form entirely new myofibers, to make the muscle stronger and more endurant (1).