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Articles by DTU Bioengineering
10.05.26 -- Solving Glycoengineering Challenges Could Begin At The Cell Line
Webinar: Scaling ADC manufacturing without compromising quality Scaling ADC programs from clinical to commercial manufacturing brings new challenges in mixing, solvent distribution, hydrophobicity, and process control. This webinar explores practical strategies and digital tools to reduce scale-up risk, including CFD modeling for conjugation, membrane strategies for TFF, and SIMCA®-online for multivariate process control, batch genealogy, and golden batch monitoring.
08.24.26 -- Is It Better To Scale Up Or Scale Out Your Cell Culture Platform?
The body as a bioreactor What if therapeutic production could move from the facility into the patient? Explore how advances in lipid nanoparticle design, delivery science, and manufacturing are helping bring the body-as-a-bioreactor vision closer to reality—and reshaping what may be possible for genomic medicine.
08.10.26 -- Why Glycoengineering Risk Starts Earlier Than Many Teams Think
Webinar: Driving Measurable Productivity Gains in CHO Cell Culture Developers are under increasing pressure to improve productivity and accelerate process development — all while building on established media platforms and workflows. Join Thermo Fisher Scientific experts and they explore how targeted media supplementation can enhance CHO cell culture performance, accelerate upstream process development, and drive measurable productivity gains without disrupting established workflows.
08.08.26 -- Bioprocess Online Newsletter - Best Of July
JULY'S BEST FEATURED EDITORIAL Why Contamination Control By Design Should Matter To Your CDMO EU GMP Annex 1 mandates a documented contamination control strategy, and FDA expectations are substantively equivalent. Let's look at why CDMOs are disproportionately exposed. Solving Glycoengineering Challenges Could Begin At The Cell Line Researchers produced a panel of platform cell lines illustrating how glycoform selection can be made experimentally visible earlier in biologics development.
07.06.26 -- Solving Glycoengineering Challenges Could Begin At The Cell Line
FOCUS ON UPSTREAM MANUFACTURING Researchers produced a panel of platform cell lines illustrating how glycoform selection can be made experimentally visible earlier in biologics development. Developing A Scalable Protocol For T Cell Activation, Expansion Explore a scalable protocol for T cell activation and expansion, designed to enhance immunotherapy workflows. This approach ensures robust T cell growth, viability, and memory phenotypes.
Solving Glycoengineering Challenges Could Begin At The Cell Line Original
By Bjørn Voldborg, DTU Bioengineering When a biopharmaceutical fails in the clinic, the conversation typically turns to sequence, dose, or formulation. Glycosylation rarely tops the list, yet the sugar structures attached to a therapeutic protein can be the difference between a drug that works and one that does not.
MGAT1 knockout in human dendritic cells enhance CD8+ T cell activation
ORIGINAL RESEARCH article Front. Immunol. Sec. Antigen Presenting Cell Biology MGAT1 knockout in human dendritic cells enhance CD8+ T cell activation Provisionally accepted 1DTU Bioengineering, Lyngby, Denmark 2Technical University of Denmark, Kongens Lyngby, Denmark The final, formatted version of the article will be published soon.
Establishment of a transparent soil system to study Bacillus subtilis chemical ecology
Soil microbial communities play a pivotal role in biogeochemical cycles and ecosystem stability on a global scale [1–3]. These communities encompass thousands of interacting species that mediate essential ecosystem services, ranging from biomass decomposition to crop productivity [4, 5].
Is there crosstalk between circadian clocks in plants and the rhizomicrobiome? - BMC Biology
References Newman A, Picot E, Davies S, Hilton S, Carré IA, Bending GD. Circadian rhythms in the plant host influence rhythmicity of rhizosphere microbiota. BMC Biol. 2022;20(1):235. Johnson CH, Zhao C, Xu Y, Mori T. Timing the day: what makes bacterial clocks tick? Nat Rev Microbiol. 2017;15:232–42. Article CAS PubMed PubMed Central Google Scholar Hubbard CJ, McMinn R, Weinig C. Rhizosphere Microbes Influence Host Circadian Clock Function. Phytobiomes J. 2021;5:368–72.
Ekspert advarer: Vi kan havne i et mangelsamfund, hvor det bliver en udfordring at dække helt basale behov
Alle ved, at vi skal stoppe med at brænde olie og andre fossile ressourcer af. Men den virkelige udfordring er alle de andre anvendelser, og hvordan de skal erstattes. Den diskussion skal på dagsordenen nu, ellers havner vi i et mangelsamfund. Der er ikke oplæsning af denne artikel, så den oplæses derfor med maskinstemme. Kontakt os gerne på automatiskoplaesning@pol.dk, hvis du hører ord, hvis udtale kan forbedres.
SHMT2 desuccinylation by SIRT5 drives cancer cell proliferation
SHMT2 desuccinylation by SIRT5 drives cancer cell proliferation Xin Yang, Zhe Wang, Xin Li, Boya Liu, Minghui Liu, Lu Liu, Shuaiyi Chen, Mengmeng Ren, Yankun Wang, Miao Yu, Bo Wang, Junhua Zou, Wei-Guo Zhu, Yuxin Yin, Wei Gu and Jianyuan Luo Cancer Res November 27 2017 DOI: 10.1158/0008-5472.CAN-17-1912
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