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Biological probes constructed from lanthanides can provide a variety of readout signals, such as the luminescence of Eu( ), Tb( ), Yb( ), Sm( ) and Dy( ), and the proton relaxation enhancement of Gd( ) and Eu( ). For numerous applications the intracellular delivery of the lanthanide probe is essential.
Carbostyrils are among the most widely used sensitising antennae for luminescent lanthanides; they afford bright complexes with Eu and Tb, and can also sensitise the emissions of the less commonly used Sm, Dy, Yb and Nd. Systematic studies on the effect of structural variations on the photophysical properties and lanthanide sensitising abilities of carbostyrils can therefore have a large impact.
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