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Dustin Becker

As seen in: Nature
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Articles by Dustin Becker

Transplantation of a human liver following 3 days of ex situ normothermic preservation - Nature Biotechnology

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By Pierre-Alain Clavien, Matteo Mueller, Dilmurodjon Eshmuminov, Lucia Bautista Borrego, Achim Weber, Brian Burg, Dustin Becker, Max Hefti, Mark W. Tibbitt
| Nature Verified
Abstract Current organ preservation methods provide a narrow window (usually <12 hours) to assess, transport and implant donor grafts for human transplantation. Here we report the transplantation of a human liver discarded by all centers, which could be preserved for several days using ex situ normothermic machine perfusion. The transplanted liver exhibited normal function, with minimal reperfusion injury and the need for only a minimal immunosuppressive regimen.
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Reply to: Lactate measurements in an integrated perfusion machine for human livers

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By Dilmurodjon Eshmuminov, Lucia Bautista Borrego, Matteo Mueller, Dustin Becker
| Nature Verified
Fig. 1: Lactate clearance during ex vivo perfusion. Data availability Data from this study will be made available upon reasonable request to the corresponding author. References 1. Stephenson, B. T. F., Afford, S. C., Mergental, H. & Mirza, D. F. Lactate measurements in an integrated perfusion machine for human livers. Nat. Biotechnol. https://doi.org/10.1038/s41587-020-0626-9 (2020). 2. Eshmuminov, D. et al. An integrated perfusion machine preserves injured human livers for 1 week. Nat. Biotechnol.
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