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The recommended standard of care for patients after resection of stage III colon cancer is adjuvant 5FU‐based chemotherapy – FOLFOX (fluorouracil, leucovorin with oxaliplatin) – or CAPOX (capecitabine, oxaliplatin). This may be modified in older patients or depending on comorbidity. This has been challenged recently, as the apparent benefit of adjuvant chemotherapy may arise from improvements in surgery or preoperative imaging or pathology staging.
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