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Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motoneurons and progressive muscle wasting. Inflammatory processes, mediated by non‐neuronal cells, such as glial cells, are known to contribute to disease progression. Inflammasomes consist of pattern recognition receptors (PRRs), apoptosis‐associated speck‐like protein (ASC) and caspase 1 and are essential for interleukin (IL) processing and a rapid immune response after tissue damage.
Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motoneurons and progressive muscle wasting. Inflammatory processes, mediated by non‐neuronal cells, such as glial cells, are known to contribute to disease progression. Inflammasomes consist of pattern recognition receptors (PRRs), apoptosis‐associated speck‐like protein (ASC) and caspase 1 and are essential for interleukin (IL) processing and a rapid immune response after tissue damage.
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