Background: Colorectal cancer (CRC) is a common and lethal malignancy which is related to aging, with almost 40% of CRC diagnosed above 75 years in both Australia and the United States. Adjuvant chemotherapy is a key treatment in patients with Stage III colorectal cancer, and combination chemotherapy using a fluoropyrimidine and oxaliplatin doublet (such as FOLFOX or XELOX) is the current standard of care, with a 20% reduction in risk of death compared to fluoropyrimidine monotherapy. It is not …